The complete origin of the Widow is revealed through the diary of Dr. Langford Harrow.

Melodie, a pregnant junkie prostitute, is drugged and taken from the Florida coast to Harrow's remote Carribean island. There Harrow injects her with his spider serum. This speeds up the pregnancy. When Melodie is about to give birth, he kills her with a powerful sedative and delivers the babies, a mutilated boy and a human looking girl. The boy is named Adam and locked away. The girl, named Emma, is growing fast and after two and a half years, she's looking like a twenty year old woman. Through fear and sedatives, Harrow has complete control over Emma.